Histology und Histopathology
Microscopy Solutions for Histology and Histopathology – Microscopic Examination of Tissue Morphology
Pathology, histopathology or histology aims to study the manifestation of disease by microscopic examination of tissue morphology. In pathology, the sample to be examined under the microscope usually is the result of a surgery, biopsy or autopsy after fixation, clearing/embedding and sectioning of the tissue specimen. Alternatively, frozen section processing with a cryostat is done when rapid results are required (e.g. during surgery) or fixation would be detrimental to target structures such as lipids or certain antigens.
Microscope Requirements
A very good differentiation of tissue structures and clearly visible cellular details are absolute prerequisites in pathology for carcinoma and tumor cell diagnosis. Histopathologists rely on crystal-clear images of their samples with the highest color fidelity in brightfield. Other contrasting techniques include polarization, CISH, fluorescence, immunofluorescence, or FISH microscopy. While histological and immunohistochemical stains result in a good transparency of the sample and specific staining of cellular features, it is the optical quality of the microscope, the fidelity of the attached camera for digital documentation, and the ergonomic design of the instrument that can make all the difference when screening patient samples. Automated digital slide scanning systems with class-leading optics assist with high-throughput screening and archiving.
Application Examples
- Histological section in brightfield, red: CD61; blue: nuclear counterstaining
- Immunhistology, HE staining, skin, smooth muscle Aktin, acquired with ZEISS Axiolab 5, Dr. G. Metzler, Universitäts-Hautklinik Tübingen
- Kidney of rat in brightfield, acquired with ZEISS Axioscope 5
- Histological specimen (human), CDx immunohistological stain, red: immunoreactive antigens in cytoplasm, blue: nuclear counterstaining
Further information can be found in the product brochures.
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LLS ROWIAK LaserLabSolutions GmbH
Dr. Heiko Richter
Garbsener Landstraße 10
30419 Hannover
E-Mail: ed.ka1769108150iwor-1769108150sll@s1769108150siez1769108150
Phone: +49 511 277 2952