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Phospho1 phosphatase in bone biomineralization - Laser Microtomy applied for histology

The research group around Prof. Alan Boyde (Queen Mary University of London) and partners has published a study in Journal of Anatomy, which contributes to clarification of the role of Phospho1 phosphatase in the initiation of mineralization of bone using a Phospho1-deficient mouse model.

Physiological biomineralization of bone is a complex cascade of biochemical and cellular events and Phospho1 is prominent in bone and participates in the formation of the initial hydroxyapatite seed crystals. Backscattered-electron scanning electron microscopy, X-ray micro-tomography and light microscopy were applied to investigate bone mineralization. The histological sections were prepared by laser microtomy.


Original publication:


Boyde A., Staines K.A., Javaheri B., Millan J.L., Pitsillides A. A., Farquharson C. (2017)
A distinctive patchy osteomalacia characterises Phospho1 deficient mice. Journal of Anatomy, J. Anat. (2017) 231, pp298—308


About LLS ROWIAK LaserLabSolutions GmbH
LLS ROWIAK LaserLabSolutions GmbH offers laser instruments for imaging, and tissue and material processing, and cell manipulation. It also provides services in tissue and material sample preparation, and is your expert partner for laser application research in Life and Material Sciences. Its basic technology is laser-based three dimensional, non contact cutting of tissue and materials and manipulation at cellular and sub-cellular level. For more information see


For more Information please contact:
Dr. Birgitta Stolze

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